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14 Y/M with fever and weakness

 THIS IS AN ONLINE E LOG BOOK TO DISCUSS OUR PATIENT'S DE - IDENTIFIED HEALTH DATA SHARED AFTER TAKING HIS / HER /GUARDIAN'S SIGNED INFORMED CONSENT .HERE WE DISCUSS OUR INDIVIDUAL PATIENT'S PROBLEMS THROUGH SERIES OF INPUTS FROM AVAILABLE GLOBAL ONLINE COMMUNITY OF EXPERTS WITH AN AIM TO SOLVE THOSE CLINICAL PROBLEMS WITH COLLECTIVE CURRENT BEST EVIDENCE BASED INPUT.    


This E blog also reflects my patient centered online learning portfolio and your valuable inputs on the comment box is welcome. 


I have been given this case to solve in an attempt to understand the topic of " patient clinical data analysis" to develop my competency in reading and comprehending clinical data including history, clinical findings, investigations and come up with diagnosis and treatment plan 

13 year old male came to OPD with chief complaints of 

Weakness since 10 days 

Fever since 2 days


History of present illness

7 March 2009

1 year old male child was brought with complaints of Not gaining weight since last 3 months

Delayed mile stones since last 3 months, loose motions/ vomitings on & off since 3 months

HOPI : Child was appasently asymptomatic 3 months back than child was not gaining weight, loose motions greenish in colour, watery in character 25- 30 times a day, not associated with blood & mucus, vomitings 4-5 times, non bilious/ non projectile, No history of ear discharge, History of recurrent cough, No history of decrease in urine out put, No history of cyanosis,.

Antenatal history: Mother had regular AN checkups, had 2 doses of T.T, Had IFA prophylaxis, No history of DM/HTN/TB, No history of prom/APH, Birth history: SPVD cryed immeditaly after birth, birth weight 4.25Kgs, Post nenotal history: MSL NICU admission for 1 day, excsive Breast feeds from 2nd day of life, exclusive breast feeds till 6 months, F/B weahing started with cerelac continued till 10 months, than child had loose motions/, stopped cerelac / Breast feeding started with MCT 130ml for 1 scoop continue only simyl/MC /now also. Now child is not taking glind diet also. Development history: Development was asymptomtic till 10th month than delay in mile stones, Global delay in all fealds with bones. O/E: Child dull, Pulse well felt, HR 90/min, RR 26/min, Heart s1 s2+, Lungs BAe+ clear, P/A soft, old man look, folds skin, loss of buccal pad of fat


At 9 years of age - parents noticed neck swelling and they took him to ENT doctor later referred to

endocrinologist where he was diagnosed with hypothyroidism - intial TSH was -150, he was started with 150 mcg of thyronorm, later increased to 180 mcg patient also gives history of chronic itching over hands and foot since the age of 9 years.



At 12 years of age patient had chicken pox resolved over 10 days.

At the age of 13 years (06.01.2022)- he came with history of yellowish discoloration of eyes since 9 days. One episode of bilious vomiting. He also complaints of  fever ,pain abdomen, loose stools.No cold, cough No history of small joint pains. colored urine .No pale colored stools .No He was treated by a pediatrician for jaundice, but as the bilirubin is increasing they referred here for further management. On examination - He is thin built.Height -156 cm Weight - 32kgs Jaundice + pallor + Per abdomen - moderate splenomegaly was noted


At 14 years of age 

He presents to us with the complaints of weakness since 10 days , when the mother noticed child appears to be dull

5 days ago the parents noticed a swelling in the groin and 2 days onwards the child has fever that was insidious in onset, spikes were noted in the morning and night hours associated with body pains. No h/o vomitings , headache or any drug intake.


Family history 

He is a 4th order child, born out of grade 4 consanguinous marriage He has 2 elder brothers and one elder sister - who expired at 5 years of age His sister was the first child and she was asymoptomatic till 2 years of age,then she had shortness of breath and was rushed to hospital, where the condition detiorated and she got admitted. They were told that she had splenomegaly and her blood counts were decreasing. She was given multiple blood transfusions every 25 days for one year inspite of that she remained anemic,she also underwent bone marrow biopsy twice .According to parents she was given steriods also for one year before death she never had jaundice or recurrent infections.

Elder brother is 19 year old and second brother is -16 years old .Second one had history of fever ,white coloured loose stools at the age of 5 years for which they went to nalgonda hospital.He was given some medications and it got resolved .But he was said to have anemia,and he recovered according to parents with some medications. There was no jaundice and no history of blood transfusion.


General physical examination

Patient is conscious ,coherent and cooperative and well oriented to time, place and person.

moderately built and nourished.

Pallor-present

Icterus-absent

Cyanosis-absent

Clubbing-absent

Lymphadenopathy-present(inguinal,cervical)

Edema-absent


Vitals:

Temperature - 99.5*c

PR :- 89bpm

RR :-20cpm

BP :- 110/80mm Hg

GRBS :-83mg/dl








Systemic examination:

CVS- S1 S2 heard no murmurs 

RS-BAE+

CNS- NFND

P/A-hard on left side,tenderness present in left hypochondriac,left lumbar and umbilical region.


Investigations:











Haemogram 

25-08-2022



27-08-2022


30-08-2022


1-09-2022



ECG





USG

Thyroid 




Abdomen



Provisional diagnosis :

Autoimmune hemolytic anemia with thyroidits.

Pancytopenia with massive splenomegaly.


Treatment:

Inj.NEOMOL 1gm iv sos(if temp > 101*F)

Tab Dolo 650 mg po TID

Tab levocitrizine 5mg po sos

Syp Ascorii-D 10ml po bd

Tab thyronorm 20mcg po OD 

Inj optineuron 1amp in 100ml NS iv OD 

Feb

He was referred to higher centre in view of portal hypertension secondary to ?NCPH/IPH, given the background of hypersplenism, massive splenomegaly with liver profile normal, portal vein doppler showing portal vein of diameter 1.6cms, with patent hepatic artery and vein, no collaterals and no ascites

Bone marrow biopsy and lymph node biopsy showed reactive with no evidence of infiltrative ethology or malignancy

20 days back he had history of pain abdomen and was admitted in the hospital in their vicinity and was advised splenectomy.
 
On Feb 1 2023, Splenectomy was done.
 
Reference
https://raveen7795.blogspot.com/2022/11/14m-massive-splenomegaly.html?m=1
















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